Thursday, March 30, 2023

Monoclonal antibodies for Yellow fever?

 LINK


The team manufactured these two monoclonal antibodies in the lab and studied how protective they could be against the yellow fever virus in two animal species: rhesus macaque monkeys and hamsters. After animals were exposed to the virus, each species was divided into three groups: one group that received the first antibody, another that received the second antibody, and a third that didn't receive either antibody.The virus couldn't be detected in blood samples of any of the animals—eight rhesus macaques and 20 hamsters—that received either monoclonal antibody. All those in the control group developed severe disease.

 

While one treated hamster died of an unknown cause, it neither showed signs of a yellow fever infection nor did it have signs of an adverse reaction to the monoclonal antibody. Both monoclonal antibody candidates also appeared to be safe. None of the animals that received either experimental treatment displayed liver dysfunction, a telltale sign of severe yellow fever infection and yellow fever vaccine-associated disease.


so far so good.

But why did the article show an illustration of the covid virus, not the Yellow fever virus? 

and why did they include the usual blame it on global warming memo, when the dirty little secret is that mosquitoes that carry yellow fever have long been found in termperate climates?

the 1793 Yellow fever epidemic of Philadelphia killed over 5000 people.

and they note that dengue could possibly be treated this way.

The problem with the experiment was that essentially they were quickly killing a virus after exposure, not seeing if it helped sick people.

So essentially giving monoclonal antibodies is similar to the old fashioned way of giving hyperimmune gamma globulin antibodies (either human or horse origin) to people exposed to a disease.

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