Tuesday, September 1, 2026

are Rabies cases in the USA missed by doctors?

from Sci Alert:

Over 90% of Human Rabies Cases in The US Aren't Detected, Study Finds

the story is that they found a person got rabies from an organ transplant. And the donor was never diagnosed as dying of rabies.

I remember a similar case in Texas where we had once sent a person for a heart transplant.

Records show it was only the fourth time in US history that an organ transplant procedure had transmitted the rabies virus (Lyssavirus rabies) from an initially undiagnosed donor. But what if these kinds of records are wrong?

Even though the Michigan patient fatality represents only the fourth known case of a transplanted fatal rabies infection – the first such instance occurring in 1978 – given how rare organ donation itself is, something just doesn't add up.

if you extrapolate the data to the general population it might suggest hundreds of cases are missed.

Sunday, August 30, 2026

Tuesday, August 18, 2026

if y ou liked gain of function frankenviruses you will love this

but they are not aimed at killing mammals or people, but bacteria.

AI-created bacteriophage overcame resistant bacterial strains, but experts emphasize need for safeguards

  researchers from Stanford University and the Broad Institute report that the functional bacteriophages they created using artificial intelligence (AI) rapidly destroyed strains of Escherichia coli that had evolved resistance to naturally occurring phages, but experts call for safeguards to prevent the technology from being used for harm.

 

Bacteriophages are ubiquitous viruses that target, infect, and kill only bacteria. They are found everywhere bacteria live, including the environment and the human gut, and they can be used to treat bacterial infections.

 

Using the ΦX174 bacteriophage as a model, the team combined their previously built genomic language models with computational biology to produce 16 complete bacteriophages with substantially different genomes.

 

“Even the simplest genomes are highly complex and can be rendered nonviable by a single mutation,” the authors wrote. “Design at the scale of whole genomes has remained largely beyond reach.” Urgent biosafety, biosecurity questions Some engineered phages performed comparably to naturally occurring relatives, and some combinations overcame two strains of E coli resistant to ΦX174-like phages.