refers to this article:
Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination
COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post-vaccination syndrome (PVS).
To explore potential pathobiological features associated with PVS, we conducted a decentralized, cross-sectional study involving 42 PVS participants and 22 healthy controls enrolled in the Yale LISTEN study. Compared with controls, PVS participants exhibited differences in immune profiles, including reduced circulating memory and effector CD4 T cells (type 1 and type 2) and an increase in TNFα+ CD8 T cells. PVS participants also had lower anti-spike antibody titers, primarily due to fewer vaccine doses.
Serological evidence of recent Epstein-Barr virus (EBV) reactivation was observed more frequently in PVS participants. Further, individuals with PVS exhibited elevated levels of circulating spike protein compared to healthy controls. These findings reveal potential immune differences in individuals with PVS that merit further investigation to better understand this condition and inform future research into diagnostic and therapeutic approaches.
We docs see this after mononuclosis (EBV mentioned above), after Myco Pneumonia cases, and maybe Gulf War syndrome is related to this.
2022 article:
I have a similar syndrome after my atypical but complicated dengue infection 19 months ago (hemorrhagic dengue with neurological symptoms)
from this article:
According to the cited definition, a minority of individuals may develop adverse effects, including autoimmune syndromes, after applying a vaccine. The central hypothesis proposed to explain the development of these autoimmune syndromes is molecular mimicry.
According to this hypothesis, the antigen administered with the vaccine, denominated adjuvants (aluminum salts, virosomes, oil-in-water emulsions, immune modulatory complexes, squalene, montanide, lipovant, and xenobiotic adjuvants) entertain structural similarities with self-antigens. Another mechanism is the activation of “innocent bystanders,” leading to autoreactive T cells, polyclonal activation, and epitope spreading; however, the pathogenic mechanisms behind the correlation between vaccines and autoimmune diseases are not yet present fully elucidated ....
The first systematic review of the literature on new-onset autoimmune syndromes after the COVID-19 vaccine was published in December 2021 [23]. In this study, 276 published cases were identified.
The mainstream cases corresponded to Guillain-Barré syndrome (151 patients) followed by vaccine-induced thrombotic thrombocytopenia (93 cases). Less frequent cases, such as autoimmune liver diseases (eight cases), immune thrombocytopenic purpura (seven cases), IgA nephropathy (five), autoimmune polyarthritis (two), rheumatoid arthritis (two), Graves’ disease (four), or systemic lupus erythematosus (three), have been reported as well. Multicenter studies have been carried out to continue informing the scientific community, in addition to informing on the indisputable advantages of vaccines against COVID-19 in groups of patients who presented autoimmune syndromes shortly after applying the first or second dose of the vaccine.
this article discusses Gulf War syndrome and post Covid syndrome similarities.
Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome
Here we first provide a brief description of 3 conditions characterized by persistent long-term symptoms, namely long-COVID-19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and Gulf War Illness (GWI), followed by a brief overview of the role of HLA in the immune response to foreign antigens. We then discuss our Persistent Antigen (PA) hypothesis and highlight associations between antigen persistence due to HLA-antigen incongruence and chronic health conditions in general and the 3 “long” diseases above in particular.
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