neuroanatomical correlates of substance involvement may, at least partially, reflect predisposing risk factors, in addition to direct consequences of use. This broadly aligns with genetically informed models hypothesizing that neurobiological correlates of addiction may reflect both causes and consequences,26 as well as with developmental theories (eg, dual-systems or maturational imbalance models) highlighting brain development as a predispositional factor for substance involvement.27,28
Lots of questions:
abnormal brain mens kids seek to use drugs?
Drug use causes the brain to change?
Drug use during pregnancy caused the brain abnormalities?
poor with malnutrition?
Poor with drug using parents?
Drug using parents because they had brain problems
Malnutrition because poverty and drug use predispose kids to brain abnormalities
not mentioned: Pollution in the environment, including lead in the air, a common cause of low grade lead poisoning before the environmental air laws in the US started.
And then we have chemicals in fast foods.
A lot of this could be cross checked into places or into history when pot use was rare (e.g. in the US prior to the Beatles etc pushed teens to use drugs, or in countries where marijuana is not used).
However, given globalization of both fast foods, air pollution and the drug trade one wonders where one could find this.
Maybe in the Amish or LDS or Seventh day Adventist communities? I left out the Baptists and Pentecostals because those communities often have converts who join to cure their impulse to take drugs.
On the other hand, maybe in autopsy records from before the 1930s...
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