this article remembers the problem with the RSV vaccine of the 1960s
For COVID-19, the fear can be traced back to an infamous clinical trial in the 1960s for an experimental vaccine against respiratory syncytial virus (RSV), the most common cause of pneumonia in children. The vaccine used an inactivated form of the virus, but almost 80 percent of the children who were vaccinated and later exposed to the real virus were hospitalized for severe illness. Two toddlers died. The boys' deaths stopped RSV vaccine development for decades—and was one reason scientists pursued the novel MRNA vaccine design against COVID-19 instead of using an inactivated form of the respiratory virus.
The cause of these toddlers' deaths was a medical mystery for decades—until now, according to a new study co-authored by Tulane University researchers in the journal Science Translational Medicine.
Italics mine.
But didn't Sinovax, the Chinese vaccine, use an inactivated version of covid? And did the outbreaks in countries using sinovax result in more fatal cases? And didn't most of the varients such as the delta varient, come from countries that used a lot of Sinovax/
I wonder, and am posting this now as a book mark/
More of the article below.
Scientists from Tulane University School of Medicine were able to delicately peel back the layers of 50-year-old medical slides containing lung tissue samples from the children to perform a detailed analysis of gene expression and study their immune response. Researchers compared the results to a control group using a similar analysis of more recent tissue slides from age and race-matched children who died from non-pulmonary causes.
After encountering RSV infection, the toddlers from the 1960s developed lung injury that damaged critical lung cells, said study co-corresponding author Dr. Jay Kolls, John W Deming Endowed Chair in Internal Medicine at Tulane School of Medicine.
"These two children died likely due to injury to surfactant producing cells in the lung that are critical for transporting oxygen to the blood," Kolls said. "Our study provides a comprehensive characterization of fatal enhanced respiratory disease, a tragedy that hampered RSV vaccine development for decades."\\
this report of the experimental use of the Chinese vaccine in UAE reported it worked 100 percent and had few minor side effects.
Sinopharm COVID-19 vaccine is an inactivated vaccine that introduces a dead copy of SARS-CoV-2 into the body by a two-dose schedule, with 14 or 21 days between the 2 doses. By inserting the vaccine dose intramuscularly, the dead antigens from the virus are employed to make antibodies that prepare the immune system for future attacks by the virus. (
Forni and Mantovani, 2021).Xia et al., 2021). The traditional inactivated whole-virus vaccines do not lead to clinical disease. In this technology, the inactivated viruses maintain their ability to replicate in vivo with mild or no symptoms (
China lies all the time, but you can see why this information will be pushed and the Chinese bots will push the problems with the US vaccines.
Business insider reports (JUNE 2021) that a lot of countries using the Chinese vaccines ended up with epidemics.
so now China is saying that hey it only prevents severe disease, not the disease itself: Something that is now being claimed for the stronger US vaccines now that there are breakthru cases.
and here is an article on the problem of the spike protein.
The Study
The vascular endothelium is an important player in the illness and death associated with COVID-19. The endothelium is a system of cells that line and protect the inside of blood vessels. SARS-CoV2 injures the endothelium leading to blood clots, heart attack, pulmonary embolism, and stroke. Despite the established link between COVID-19 and these cardiovascular complications, the mechanism by which they develop is unknown.
Researchers from Jiaotong University; the University of California, San Diego; and the Salk Institute used a pseudovirus coated with spike protein to investigate the effects of the viral protein on endothelial cells. Pseudoviruses – which were first developed over 50 years ago – contain the outer shell of the virus, but they lack the viral genes needed to reproduce.
Hamsters treated with the spike protein coated pseudovirus showed lung damage similar to that seen in humans infected with SARS-CoV2. When researchers added pseudovirus to cultured endothelial cells they found that the mitochondria inside the cells were injured. Since mitochondria are responsible for providing energy to cells, their dysfunction can cause cell death.
When isolated pulmonary arteries were exposed to the spike protein carrying pseudovirus there was some disruption in the ability of the blood vessels to dilate. The decreased ability to expand blood vessels that serve the lungs could impair the ability of the body to take up oxygen from lungs that are damaged by the virus.
The novelty of this study was the discovery that the spike protein itself causes damage, and that the pathway triggered by the spike protein could explain the widespread cardiovascular complications that develop in COVID-19 patients.
A Twisted Tale
Shortly after Lei and colleagues published their study, vaccine skeptics touted the findings as proof that newly developed COVID-19 vaccines are dangerous. Afterall, if COVID-19 vaccines produce spike protein to trigger immunity, and that same spike protein causes injury, then vaccines are really no different than the disease they are designed to prevent.
The problem with these claims is that science doesn’t support their arguments.
The Long Road to Perdition
COVID19 vaccines are injected into the deltoid where they are taken up by muscle cells. The vaccine remains largely contained near the site of injection. Local muscle cells that take in the vaccine produce the spike protein and place it on the surface of the cell where it is recognized by the immune system. Vaccine that is not taken up by muscle is drained into the local lymph nodes where lymphatic cells absorb the vaccine and similarly make spike protein. The lymphatic cells are responsible for activating T and B cells, which are important steps in generating immunity.
In order to damage the endothelium of blood vessels, COVID-19 vaccines have to enter the vascular system and infect cells that circulate in the blood. Data collected by the European Medicines Agency shows that no significant amount of vaccine enters the circulation. The confinement of the expressed spike protein away from the circulatory system significant prevents it from causing damage to the vascular endothelium.
...................................................hmm... Dr Campbell, a nurse epidemiologist on you tube, has mentioned in several videos that the US technique of not withdrawing before injection might have led to intra arterial injection causing blood clot problems:
more here
Redesigning the Spike Protein
The spike protein attaches SARS-CoV2 to cells through a receptor called ACE2. In order to fully interact, the spike protein must undergo a conformational change.
A research team lead by Dr. Barney Graham from the Vaccine Research Center at the NIH National Institute of Allergy and Infectious Diseases created an engineered form of the spike protein that is unable to make the shape change required to effectively bind to cells. The Pfizer/BioNTech, Moderna, Novavax, and Johnson&Johnson vaccines all use this inactivated spike protein, which means any spike protein that is produced by the vaccine is not able to be activated. This safety-switch limits the ability of the spike protein to bind ACE2 and limits its ability to cause damage.
Stuck in a Hole
In addition to engineering the spike protein so it can not be fully activated, the protein is tagged with an extra piece called a “transmembrane anchor”. The transmembrane anchor allows the spike protein to appear on the surface – or membrane – of the cell, but it is held in place by the anchor. This prevents the spike protein from drifting away and creates a fixed target for the immune system to recognize the foreign protein.
No comments:
Post a Comment