Sunday, August 20, 2023

Covid, Zika and... Dengue?



the scandal: This was stopped by propaganda and actually punishing docs and families who tried to use it, but other expensive and new anti virals that had a similar success rate (i.e. not very good) were used.

yet the side effects of ivermectin are few (unlike HCQ, which can kill you if you overdose, which is why the mortality in Brazil was higher when this was used: They used too high a dose and it affected people with heart disease).

I only used Ivermectin once for a chest cold just in case it was covid. I get these infections once or twice a year normall, and I had three such infections in the lockdown time for Covid ...for the first two I used my regular steroids and antibiotics; the third time we had bought some ivermectin because Duterte refused to ban it, saying you could take it if your doc prescribed it. 

But you know, I was not aware of that it might help Dengue too:  that it has been used experimentally for Dengue, zika and other viruses,.


Nature magazine:journal of antibiotics:June 2020.

Abstract Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting.

here is the part about Dengue: 

Dengue virus, yellow fever virus (YFV), and West Nile virus (WNV)... It may be concluded that ivermectin could be effective in the early stages of infection and maybe a recommended drug for the prevention or treatment of early stages of viral infection, rather than advanced forms. Of course, confirmation of this statement requires further human studies and clinical trials

link2: shows one problem with the medicine: poor water solubility means that oral medicine might not give a high enough dosage.

One reason I didn't think I had dengue was lack of headache and muscle pain.

My Dengue was atypical, mainly severe weakness, and fever, no pain no cough so I didn't think I had covid, and of course my covid was negative test but the low wbc and a dropping platelet count suggested dengue, and the igM of Dengue was positive on the third day.'

We have a lot of dengue in the area, and most cases are treated at home, usually with antibiotics, which don't help Dengue of course but hey when your wbc goes down to 2000, it means your body can't fight off bacterial infections. LINK.

The clinical course of a viral infection can be adversely affected by bacterial coinfection.6–8 However, bacterial coinfection can be easily overlooked in dengue-endemic or -epidemic settings. A simple clinical rule for the identification of concurrent bacterial infection in dengue patients would be pivotal for triggering timely antibiotic therapy within the usual context of supportive management.

Of 2,065 patients, 83 (4.0%) patients had 110 instances of bacterial coinfection marked by positive blood culture (25/110; 22.7%), positive urine culture (43/110; 39.1%), or physician-diagnosed bacterial pneumonia (42/110; 38.2%).

so low rate of secondary bacterial infections but if the patient is sick you might want to treat them just in case.

No comments:

Post a Comment